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Tuesday, October 24, 2006

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The Women's Health Initiative (WHI) study reported increased risks of myocardial infarction, stroke, invasive breast cancer, pulmonary emboli, and deep vein thrombosis in postmenopausal women (50-79 years of age) during 5 years of treatment with oral conjugated estrogens combined with medroxyprogesterone acetate.

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Ű high levels of cholesterol or triglycerides in the blood;ʨydrocortisone, cortisone, or prednisolone Ő The Women's Health Initiative Memory Study (WHIMS) found that postmenopausal women 65 years of age or older who were treated with oral conjugated estrogens plus medroxyprogesterone acetate had an increased risk of developing dementia. It is unknown whether this finding applies to youestrace
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nger postmenopausal women or to women using estrogen only therapy.ʲifabutin, rifampin, or rifapentineʩncreased or decreased appetite Ű liver disease; Ő Estradiol may be administered by mouth, injection, or inserted into the vagina. Your healthcare provider may administer injections of estradiol or will provide you with detailed instructions on how to administer the medication at home.ʹellowing of the eyes or skin Ő The Women's Health Initiative Memory Stu

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dy (WHIMS) found that postmenopausal women 65 years of age or older wh

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o were treated with oral conjugated estrogens plus medroxyprogesterone acetate had an inc

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reased risk of developing dementia.

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It is unknown whether this finding applies to younger postmenopausal women or to women using estrogen only therapy.ʴheophyllineestrac

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e vaginal creamAvailable Product Images:ʳome medications for treating migrainesʭood changes, anxiety, depression, frustration, anger, or emotional outburstsIn women who still have their uterus, estrogens increase the risk of developing estrace
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a condition (endometrial yperplasia

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) that may lead to cancer of the lining of the uterus. Taking progestins, another hormone drug, with estrogens lowers the risk of developing this condition. Therefore, if your uterus has not been removed (by a hysterectomy), your doctor may prescribe a progestin for you to take together with your estrogen. You should know, however, that taking estrogens with progestins may have

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additional health risks. You should discuss the use of estrogens and progestins with your health care professional to determine the benefits and risks for you.ʡsthmaŐ Take each oral dose with a full glass of water. Ű a history of stroke or heart attack; Ő Estrace may decrease milk flow and have other effects on milk composition. Do not use this medication without first talking to your doctor if you are breast-feeding a baby.S

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ide effects that usually do not require medical attention (report to your prescriber or health care professional if they continue or are bothersome):ʨormonesʤiabetes
Contact your pediatrician or health care professional r

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egarding the use of this medicine in children. Special care may be needed.

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Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Throw away any unused medicine after the expiration date.1. ESTROGENS HAVE BEEN REPORTED TO INCREASE THE RISK OF ENDOMETRIAL CARCINOMA IN POSTMENOPAUSAL WOMEN.

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ʢlood vessel disease, blood clotting disorder, or suffered a stroke
What should I watch for while taking e

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stradiol? (Back to top)
ʨigh level of calcium in the bloodTake estrogen tablets by mouth. Follow the directions on the prescription label. Swallow the tablets with a drink of water. If the tablets upset your stomach, take them with food or milk. Take your doses at regular intervals; estrogens work best when taken at the same time each day. Do not take your medicine more often than directed.
ʨysterectomyIf you have any reason to think you are pregnant; stop taking estrogens at once and contact your prescriber or health care professional.ʷarfarinʰorphyriaestradiol (oral, injectable, and vaginal) (ess tra DYE ole)

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Ő Taking Estrace may not be recommended in soe cases if you have any of the conditi

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ons listed above.ʤantroleneʴhyroid hormonesʳevere headachemedications for diabetes Ő Use injectable estradiol exactly as directed by your healthcare provider. Do not inject any estradiol product that is discolored or has particles

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in it. Injectable estradiol stored at cool temperatures may develop crystals in the solution, which should dissolve as the solution warms to room temperature.Tell your prescriber or health care professional about all other medicines you are taking, including non-prescription medicines, nutritional supplements, or herba

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l products. Also tell your prescriber or health care professional if you are a frequent user of drinks with caffeine or alcohol, if you smoke, or if you use illegal drugs. These may affect the way your medicine works

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. Check with your health care professional before stopping or starting any of your medicines.Estrogen therapy during pregnancy is aestrace
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ssociated with an increased risk of congenital defects in the reproductive organs of the fetus, and possibly other birth defects. Studies of women who received diethylstilbestrol (DES) during pregnancy have shown that female offspring have an increased risk of vaginal adenosis, squamous cell dysplasia of the uterine cervix, and clear cell vaginal cancer later in life; male offspring have an increased risk of urogenital abnormalities and possibly testicular cancer later in life. The 1985 DES Task Force concluded that the use of DES dur

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ing preg

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nancy is associated with a subsequent increased risk of breast cancer in the mothers, although a causal relationship remains unproven and the observed level of excess ʴopiramate Ő Estrace is in the FDA pregnancy category X. This means that Estrace is known to cause birth defects in an unborn baby. Do not take this medication if you are pregnant or could become pregnant during treatment.ʢarbiturates or benzodiazepines used for inducing sleep or treating seizures (convulsions) Ű gallbladder disease;What are estradiol tablets? (Back to top) Ő Estrace may also be used for purposes other than those listed in this medication guideʣyclosporineʳtomach or abdominal pain (severe)What side effects may I notice from taking stradiol? (Back to top)What

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drug(s) may interact with estradiol? (Back to top)What if I miss a ose? (Back to top) Ő Take this medication exactly as directed by your doctor. If you do not understand these irections, ask your phar

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macist, nurse, or doctor to explain them to you.
ʶision or speech problemsʨeart, kidney or liver diseaseʣhest pain
What are estradiol tablets?What should I watch for whil taking estradiol?
ʭethotrexateʡscorbic acid/vitamin C supplements

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Ű epilepsy;ʴobacco smoker
Ő You may not be able to take Estrace, or you may require a dosage adjustment or special monitoring during treatment if you h

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ave any of the conditions list
ʮausea, vomiting
ʰhenytoin Ő Do not take Estrace without first talking to your doctor if you haveestrace side effectsThey need to know if you have any of these conditions:
ʷeight gain

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Active Ingredients: Estradiol ʳome medications used to treat HIV (human immunodeficiency virus) infection or AIDS
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ʢreast-feedingHow should I take this medicine? (Back to top)
Where can I keep my medicine? (Back to top)
ʧriseofulvin
Where can I keep my medicine?

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Ő The Women's Health Initiative (WHI) study reported increased risks of myocardial infarction, stroke, invasive breast cancer, pulmonary emboli, and deep vein thrombosis in postmenopausal women (50-79 years of age) during 5 years of treatment with oral conjugated estrogens combined with medroxyprogesterone acet

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ate.
ʭigraine
What side effects may I notice from taking estradiol?

Ő Treatment with Estrace long-term may increase the risk of stroke. Because of this risk, you should contact your doctor or healthcare provider to discuss your individual risks and benefits before taking Estrace long-term. You sh

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ould also talk to your doctor or healthcare provider on a regular basis (for example, every 3-6 months) about whether you should continue this treatment.
Ő Treatment with Estrace long-term may in

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crease the risk of stroke. Because of this risk, you should contact your doctor or healthcare provider to discuss your individual risks and benefits before taking Estrace long-term. You should also talk to your doctor or healthcare provider on a regular basis (for example, every 3-6 months) about whether you should continue this treatment.
If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose and resume your normal sch

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edule. Do not take double or extra doses.estrace
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Ű kidney disease;
What should I discuss with my healthcare provider before taking Estrace?
What is the most important information I should know about Estrace?
ʢreast, cervical, endometrial or uterine cancer

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What should my health care professional know before I take estradiol?
ʢreakthrough bleeding and spotting
If you are going to have elective surgery, you may need to stop taking your estrogens one month beforehand. Consult your health care

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professional for advice prior to scheduling the surgery.
ʡn unusual or allergic reaction to estrogens, other hormones, medicines, foods, dyes, or preservatives

ʨigh blood pressure
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ʦibroids in the womb, or endometriosis

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Ű had a hysterectomy (uterus removed).
If you wear contact lenses and notice visual changes, or if the lenses begin to feel uncomfortable, consult your eye care specialist or health care professional.
ʩsoniazid (INH)
ʦor all uses of this medicine:

How should I take Estrace?

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ESTRADIOL (Estraceé are estrogens th

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at are essential for maintaining normal female functions. Estradiol is normally produced by the ovaries. After menopause, the ovaries decrease their production of this hormone. Estrogens can help relieve symptoms of the menopause (hot flashes, night sweats, mood changes, and vaginal dryness and irritation), and help to prevent thestrace
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e onset of osteoporosis (a loss of bone mass, so that bones become brittle and easily broken). Estrogens can also help improve female functions in women with hormonal imbalance or problems with their ovaries. Estrogens may also be given to certain men or women with inoperable breast cancers or prostate cancer. Occasionally these medications are used for other purposes. Generic estradiol tablets are available.

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Ő Estradiol is used to treat sy

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mptoms of menopause such as hot flashes and dryness, burning, and irritation in the vaginal area; deficiency in ovary function (including underdevelopment of female sexual characteristics and some types of infertility); Turner's syndrome; some types of breast cancer in men and in postmenopausal women; degeneration of the vagina and urethra; and prostate cancer. In addition, Estradiol is used to prevent osteoporosis.
Ű uterine fibroids; or
Ű asthma;
Ű migraines;estrace
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ʳwelling of the hands, feet or ankles, or rapid weight gain
ʭild stomach upset
Keep out of the reach of children in a container that small children cannot open.
What is Estrace?

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ʣhange in sexual desire
ʴiredness
ʳome antibiotics used to treat infections
What drug(s) may interact with estradiol?

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2. ESTROGENS SHOULD NOT BE USED DURING PREGNANCY.
Ő Do not take Estrace if you are pregnant.
Estrace
Tobacco smoking increases the risk of getting a blood clot or having a stroke while you are taking estrogens, especially if you are more than 35 years old. You are strongly advised not to smoke.
Ű undiagnosed, abnormal vaginal bleeding; or
ʶaginal yeast infection (irritation and white discharge)

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Ő Before taking Estrace, tell your doctor if you have
Representative Names: Estrace, Gynodiol
ʲaloxifene or tamoxifen
What if I miss a dose?
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ʭental depression
There is no indication for estrogen therapy during pregnancy or during immediate postpartum period. Estrogens are ineffective for the p

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revention or treatment of threatened or habitual abortion. Estrogens are not indicated for the prevention of postpartum breast engorgement.
Ő Rotate injection sites as directed.Estradiol
ʧrapefruit juice
ʳystemic lupus erythematosus (SLE)
Ű any type of breast, uterine, or hormone-dependent cancer.
Ű a circulation, bleeding, or blood-clotting disorder;
ʣlofibrate
ʴricyclic antidepressants
Side effects that you should report to your prescriber or health care professional as soon as possible:

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Ő Take oral estradiol with food or milk to lessen stomach upset. Try to take oral doses at the same time daily.
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How should I take this medicine?
ʨigh blood lipids or cholesterol
ʳkin rash, acne, or brown spots on the face
Ű diabetes;

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ʬeg, arm or groin pain
ʢreast enlargement, tenderness, unusual discharge or milk production
Ű depression;
ʩmipramine or some other antidepressants
Close clinical surveillance of all women taking estrogens is important. Adequate diagnostic measures, including endometrial sampling when indicated, should be undertaken to rule out malignancy in all cases of undiagnosed persistent or recurring abnormal vaginal bleeding. There is no evidence that "natural" estrogen

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s are more or less hazardous than "synthetic" estrogens at equi-estrogenic doses.
ʣimetidine
Before starting this medication, read the paper on your prescription provided by your pharmacist or health care professional. This paper will tell you about the specific product you are taking. Make certain you understand the instructions.
Clinagen LA 40, Delestrogen, Depo-Estradiol, Estrace, Estrogel, Femring, Femtrace, Gynodiol, Valergen
Ő Estrace increases the risk of developing a condition (endometrial hyperplasia) that may lead to cancer of the lining of the uterus. Taking progestins, another hormone drug, with Estrace lowers the risk of developing this c

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ondition. Therefore, if your uterus has not been removed, your doctor may prescribe a progestin for you to take together with the estrogen. Visit your doctor regularly and report any unusual vaginal bleeding right away.
Ő Estradiol is a form of estrogen. Estrogen is a female sex hormone necessary for many processes in the body.
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Ű high blood pressure, angina, or heart disease;
What should my health care professional know before I take estradiol? (Back to top)
Visit your prescriber or health care professional for regular checks on your progress. You should have a complete check-up every 6 monv

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ths. You will also need a regular breast and pelvic exam and 'Pap' smear while on estrogens therapy. You should also discuss the need for regular mammograms with your health care professional, and follow his or her guidelines for these tests. If you have any unusual bleeding contact your prescriber or health care professional for advice.
Estrogens can make your body retain fluid, making your fingers, hands, or ankles swell. Your blood pressure can go up. Contact your prescriber or health care professional if you feel you are retaining fluid.
ʰregnant or trying to get pregnant
ʳudden shortness of breath

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